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KMID : 0608520060120010077
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Korean Journal of Oriental Medicine
2006 Volume.12 No. 1 p.77 ~ p.89
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The Inhibitory Effect of Mahwangbokhapbang 2 on the Obesity
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Lee Woo-Youl
Lim Byung-Muk
Oh Min-Seok
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Abstract
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Objective : This experimental study was designed to investigate the effects of Mahwanbokhapbang2 (every abbreviation from now on MHBHB2) on obesity care when it is prescribed for high fat diet-induced mice. Also designed to find out effects of MHBHB2 on controlling the obesity clinically.
Method: In order to investigate the obese inhibitory effects of MHBHB2, C57BL/6 mice were induced by high fat diet. C57BL/6 mice were divided into four group (normal, high fat diet, high fat diet with reductil, high fat diet with MHBHB2 extract) and fed for 15weeks.
Results: 1. Mahwangbokhapbang2(MHBHB2) decreased significantly the body weig-ht. 2. MHBHB2 decreased significantly the weight of adipocyte. 3. MHBHB2 decreased significantly the blood level of serum ALT, AST. 4. MHBHB2. decreased significantly the blood level of serum total cholester-1, LDL- cholesterol, triglyceride and NEFA(free fatty acid). 5. MHBHB2 increased significantly the blood level of HDL-cholesteroI. 6. MHBHB2 500㎎/㎏ decreased significantly the blood level of Leptin.
Conclusion: Based on these results, it is proved that MHBHB2 is effective on obesity care and has obese-inhibitory effects in obese-mouse induced by high fat diet. So it is espected that the clinical application of MHBHB2 can help the treatment of obesity.
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KEYWORD
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Mahwangbokhapbang2(MHBHB2), obesity, cholesterol
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